The man bitten by 200 snakes helps scientists create a super anti -antiyven

There is really a goal for everyone there. Scientists seem to have developed the most effective snake anti -anti -anti -anti -anti -anti -antibody, partly obtained by the antibodies of a person bitten by snakes hundreds of times.

Researchers from the National Health Institutes and the Centivax company detailed their work in a study published Last week in Cell. In mice tests, their cocktail protects the animals from 19 of the most poisonous snakes in the world. This study could ultimately lead to a truly universal anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -anti -antibodys, scientists say.

Currently, Antenom Snake is produced by collecting antibodies of animals (usually horses) that generate a strong immune response to toxins. Although effective, today’s anti -anomas have their limitations.

Antibodies to a specific snake or toxin often do not protect against other people, for example. Mixing different antibodies to create a cocktail may increase the effectiveness of treatment, but also increases the risk of serum– a harmful immune response of foreign proteins in the anti -ennoic.

Various research teams are striving to create a more universal and more favored antidome for a long time. Research researchers theorizes that they can develop one by studying the blood of someone who has survived that he has been bitten by many different snakes throughout his life. In the end, they found such a donor: Tim Fride.

Fride is an independent herpetologist and a poisonous serpent collector. Nearly 20 years ago, he began to be bite intentionally to build up to build the snake zones. His first bites, According to NPR, He landed him in the hospital with a coma for several days. But Fride recovered and continued his bold endeavor with less complications. Throughout his life, he has been bitten by poisonous snakes about 200 times and is further injected with more than 700 doses of poison. Realizing that he is now hyper-immune to the snake snakes, he decided to contact other scholars so that they could study it. In 2017, he finally contacted Jacob Glhanville, the founder of Centivax.

Glower and his team isolate two specific Fride antibodies, which widely neutralized many different snake toxins, which they were able to synthesize in the laboratory. Then they made a cocktail with anti -anti -sting

The cocktail with three team agents was administered to mice exposed to the poison of 19 snakes. All of these snakes belong to the lodged family of poisonous snakes and are members of the World Health Organization Category 1 and 2 snakes (most medical significant poisonous snakes in the world). The cocktail provided full protection – which means 100% survival – for mice exposed to a poison of 13 snakes, including several cobra and black mamba, and offers partial protection against six others.

Other research teams work independently Widely effective antivenomsS But the researchers say that their first such candidate derived from synthetic antibodies – all thanks to the bravery of Tim Fride, who has since become the director of herpetology at Centivax.

“What was exciting for the donor was his unique immune story once in life,” Glangil says in statement From Cell Press, the publishers of the study. “Not only does it potentially create these widely neutralizing antibodies, in this case it can lead to a wide range or universal anti -anti -anti -anti -antibody.”

Centivax continues to develop its cocktail. He hopes to test him in a trial, including dogs bitten with a snake in Australia, which are introduced into veterinary clinics. And the researchers hope that they can take things even more by developing a second cocktail that covers another large family of poisonous snakes, butterflies or mega-cocks that can cover both types of snakes at once.

If their work is paid, a truly universal anti -anti -anti -anti -medical benefits can have great medical benefits, especially in the developing world where snake areas are much more common. According to World Health Organization, Between two and four million people are poisoned by snakes annually, while approximately 100,000 die each year.